1st Edition

Vitamin B12
Advances and Insights

ISBN 9781498706995
Published January 11, 2017 by CRC Press
376 Pages 11 Color & 51 B/W Illustrations

USD $225.00

Prices & shipping based on shipping country


Book Description

Cobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was, however, based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently, the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet, environment and diseases. Conditions like aging, diet and drugs increase the risk of developing cobalamin deficiency, probably because of diminished ability to liberate, absorb or distribute the food-derived vitamin. From a basic science point of view, understanding of the transport and function of the vitamin, may pave the road for using this system for drug delivery.

This book represents up-to-date literature on the discoveries and developments in the field of cobalamin. It includes multifaceted aspects of the vitamin in health and disease conditions. The book has been written by leading scientists who have significant contributions in this field and represents therefore, a timely unique encyclopaedia on cobalamin.

Table of Contents

Milestones in the Discovery of Pernicious Anemia and Its Treatment

Jörn Schneede

Nutritional and Biochemical Aspects of Cobalamin throughout Life

Eva Greibe

Intracellular Processing and Utilization of Cobalamins

Luciana Hannibal and Donald W. Jacobsen

Inherited Defects of Cobalamin Metabolism

David Watkins and David S. Rosenblatt

Conditions and Diseases that Cause Vitamin B12 Deficiency: Form Metabolism to Diseases

Emmanuel Andrès

Vitamin B12 Deficiency in Developing and Newly Industrialising Countries

Chittaranjan Yajnik, Urmila Deshmukh, Prachi Katre and Tejas Limaye

Vitamin B12 in Neurology and Aging

Andrew McCaddon and Joshua W Miller

The Role of Cobalamin in the Central and Peripheral Nervous Systems: Mechanistic Insights

Elena Mutti

Laboratory Markers and Diagnosis of Cobalamin Deficiency

Rima Obeid

Cobalamin during Pregnancy and Lactation

Rima Obeid, Pol Solé-Navais and Michelle M Murphy

Vitamin B12 after Birth and during Early Life

Rima Obeid, Pol SoléNavais and Michelle M Murphy

Cobalamin – Folate Interactions

Pol Solé-Navais, Rima Obeid and Michelle M Murphy

Extreme Vitamin B12 Concentrations in Clinical Practice in the Absence of Symptoms or B12 Treatment

Rima Obeid

Vitamin B12 and Drug Development

Jayme L. Workinger and Robert P. Doyle

View More