1st Edition

Imaging in Photodynamic Therapy

ISBN 9781498741453
Published February 1, 2017 by CRC Press
479 Pages 250 B/W Illustrations

USD $390.00

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Book Description

This book covers the broad field of cellular, molecular, preclinical, and clinical imaging either associated with or combined with photodynamic therapy (PDT). It showcases how this approach is used clinically for cancer, infections, and diseases characterized by unwanted tissue such as atherosclerosis or blindness. Because the photosensitizers are also fluorescent, the book also addresses various imaging systems such as confocal microscopy and small animal imaging systems, and highlights how they have been used to follow and optimize treatment, and to answer important mechanistic questions. Chapters also discuss how imaging has made important contributions to clinical outcomes in skin, bladder, and brain cancers, as well as in the development of theranostic agents for detection and treatment of disease. This book provides a resource for physicians and research scientists in cell biology, microscopy, optics, molecular imaging, oncology, and drug discovery.

Table of Contents


Looking out the optical window: Physical principles and instrumentation of imaging in photodynamic therapy

Hui Liu and Jonathan P. Celli


Photochemistry and photophysics of PDT and photosensitizers

Marcin Ptaszek




Phthalocyanines in photodynamic therapy

Heidi Abrahamse


Singlet oxygen luminescence imaging: A prospective tool in bioscience?

Michael Pfitzner, Jan C. Schlothauer, Lisheng Lin, Buhong Li, and Beate Röder


Microbial biofilms and antimicrobial photodynamic therapy

Anil Kishen


High-content imaging for photosensitizer screening

Gisela M.F. Vaz, Mathias O. Senge, Sarah-Louise Ryan, and Anthony Davies




Enhanced efficacy of photodynamic therapy via an iron–lysosome–mitochondria connection: Studies with phthalocyanine 4

Anna-Liisa Nieminen, Hsin-I Hung, and John J. Lemasters


Role of cell death pathways in response to photodynamic therapy in gliomas

Leonardo Barcelos de Paula, Fernando Lucas Primo, and Antonio Claudio Tedesco


In search of specific PDT photosensitizers: Subcellular localization and cell death pathways

Tayana M. Tsubone, Christiane Pavani, Isabel O.L. Bacellar, and Maurício S. Baptista




Quantum dots in PDT

Ričardas Rotomskis and Giedre Streckyte


Tetrapyrrole-based theranostic combinations of photodynamic action and magnetic resonance imaging

Duygu Aydın Tekdaş, Devrim Atilla, Vefa Ahsen, and Ayşe Gül Gürek


Theranostic applications of photodynamic molecular beacons

Wentao Song, Yang Zhou, and Jonathan F. Lovell


Tumor-specific imaging and photodynamic therapy targeting the urokinase receptor

Zafar Iqbal, Longguang Jiang, Zhuo Chen, Cai Yuan, Rui Li, Ke Zheng, Xiaolei Zhou, Jincan Chen, Ping Hu, and Mingdong Huang




Vascular imaging in photodynamic therapy

Bin Chen


Photosensitizer activity imaging on the microscopic scale

Steffen Hackbarth


Bioluminescence imaging for monitoring the effectiveness of photodynamic therapy for infections in animal models

Pawel Mroz and Michael R. Hamblin




Imaging of photosensitizers in skin

Marica B. Ericson, Danni Wang, Despoina Kantere, John Paoli, and Ann-Marie Wennberg


Brain tumor imaging with ALA

Herbert Stepp and Oliver Schnell


PDT of non-muscle-invasive bladder cancer with Hexylester Aminolevulinate: Optimization of the illumination wavelengths by fluorescence spectroscopy and imaging

Matthieu Zellweger, Claude-André Porret, Norbert Lange, Patrice Jichlinski, Hubert van den Bergh, and Georges Wagnières


Endoscopic imaging and photodynamic therapy

Harubumi Kato, Kinya Furukawa, Yasufumi Kato, Jitsuo Usuda, Kuniharu Miyajima, and Keishi Ohtani


Spectroscopic imaging in prostate PDT

Rozhin Penjweini, Brian C. Wilson, and Timothy C. Zhu


Fluorescent-guided resection in clinical oncology

Ron R. Allison

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Michael R Hamblin Ph.D. is a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, an Associate Professor of Dermatology at Harvard Medical School and is a member of the affiliated faculty of the Harvard-MIT Division of Health Science and Technology. His research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer, and stimulation of the immune system, and in low-level light therapy (LLLT) for wound healing, arthritis, traumatic brain injury, neurodegenerative diseases and psychiatric disorders. He directs a laboratory of around a dozen post-doctoral fellows, visiting scientists and graduate students. His research program is supported by NIH, CDMRP, USAFOSR and CIMIT among other funding agencies. He has published 272 peer-reviewed articles, over 150 conference proceedings, book chapters and International abstracts and holds 8 patents. He is Associate Editor for 7 journals, on the editorial board of a further 12 journals and serves on NIH Study Sections. For the past 10 years Dr Hamblin has chaired an annual conference at SPIE Photonics West entitled "Mechanisms for low level light therapy" and he has edited the 10 proceedings volumes together with four other major textbooks on PDT and photomedicine. He has several other book projects in progress at various stages of completion. In 2011 Dr Hamblin was honored by election as a Fellow of SPIE.

Ying-Ying Huang, M.D., is a scientist in Dr. Michael Hamblin’s lab in Wellman Center for Photomedicine at Massachusetts General Hospital, an Instructor of Dermatology at Harvard Medical School. She was trained as a dermatologist in China. She has been at MGH Wellman Center for 5 years. Her research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer and mechanism of low level light therapy (LLLT) for traumatic brain injury. She has published 48 peer review articles and 15 conference proceedings and book chapters. She is the co-editor of newly released Handbook of Photomedicine


"The editors have skillfully compiled a wide and comprehensive spectrum from contributors around the world on up-to-date imaging technologies for photodynamic therapy (PDT), with a wealth of clinical images." –Optics & Photonics News