1st Edition

Glutamine
Biochemistry, Physiology, and Clinical Applications




ISBN 9781482234299
Published March 1, 2017 by CRC Press
386 Pages 8 Color & 66 B/W Illustrations

USD $165.00

Prices & shipping based on shipping country


Preview

Book Description

Glutamine: Biochemistry, Physiology, and Clinical Applications describes the different functions of glutamine (Gln) in animals and humans. Gln is both a nutrient and a signaling molecule, and its functions go beyond those of a simple metabolic fuel or protein precursor. This book has gathered together, in an unbiased and critical manner, all the available evidence and research on Gln including pathology (neurological diseases, intestinal diseases, critical illness, and cancer), physiology (successful aging), catabolic states, immunity, and exercise. Special attention is given to the potential benefit of Gln in states of insulin resistance and the role of Gln as a "conditionally essential" amino acid.

The contributors are either pioneers or experts in the area of Gln from all around the globe, including Australia, Brazil, Canada, Europe, China, and the United States. This book is a valuable source of information for nutrition scientists, medical doctors, sports scientists, food scientists, dietitians, and anyone interested in nutrition. It is also a valuable resource for students in these fields and will be an important addition to university libraries.

Table of Contents

INTRODUCTION
Morey W. Haymond

BASICS OF GLUTAMINE METABOLISM

An introduction to glutamine metabolism
Vinicius Cruzat and Philip Newsholme

NEW DATA ON THE BIOCHEMISTRY OF GLUTAMINE

Intestinal glutamine synthetase co-localizes with goblet cells and decreases enterocyte proliferation
Youji He, Theodorus BM Hakvoort, Jacqueline LM Vermeulen and Wouter H. Lamers

Glutaminase isoforms and glutamine metabolism
Curthoys et al.

MOLECULAR AND CELLULAR ASPECTS OF GLUTAMINE METABOLISM

The importance of glutamine to insulin secretion, insulin action and glycaemic control
Vinicius Cruzat, Gaewyn Ellison, Cyril Mamotte and Philip Newsholme

Glutamine and autophagy
Rolf Gebhardt

Novel aspects on the regulation of glutamine and ammonia metabolism by morphogens
Rolf Gebhardt, Jan Böttger, Eugenia Marbach, Madlen Matz-Soja

GLUTAMINE, THE BRAIN AND NEUROLOGICAL DISEASES

The role of glutamine in brain pathology
Albrecht et al.

Brain glutamine and hepatic encephalopathy
Roger F. Butterworth and Chantal Bemeur

Change of glutamate/glutamine amounts in the striatum in a murin model of Parkinson's disease
Carine Chassain1, Guy Bielicki2, Jean-Pierre Renou3, Franck Durif1,4

GLUTAMINE AND THE INTESTINAL TRACT

Glutamine and intestinal physiology and physiopathology
François Blachier1, Xiangfeng Kong2, Guoyao Wu3, Daniel Tomé1, Antonio Lancha Jr4, Mireille Andriamihaja1, Yulong Yin2

Glutamine: General Facilitator of Gut Absorption and Repair
Rhoads et al.

Therapeutic role of glutamine in inflammatory bowel disease
Hongyu Xue and Paul Wischmeyer

GLUTAMINE AND THE CATABOLIC STATE

PART I: ROLE OF GLUTAMINE IN CRITICAL ILLNESS

SECTION A: DURING CHILDHOOD

Glutamine in the Critically Ill Neonate
Neu et al

SECTION B: FROM ADULTHOOD

Rationale for and efficacy of glutamine supplementation in critical illness
Farook Jahoor, Christina Kao

The Role of Glutamine and Oxidative Injury Pathways in Critically Ill Patients
Naji Abumrad, Kaushik Mukherjee and Addison May

Glutamine supplementation in critical illness: clinical endpoints
Marie Smedberg and Jan Wernerman

Glutamine supplementation in critical illness: action mechanisms
Moïse Coëffier and Pierre Déchelotte

The clinical role of glutamine supplementation in disease
Giacomo Garibotto, Alice Bonanni, Giacomo Deferrari, Daniela Verzola

PART II: ROLE OF GLUTAMINE IN CANCER

Glutamine transport and metabolism in cancer
Paige J. Bothwell, Clare C. Kron and Barrie P. Bode

Glutamine as a new therapeutic target in cancer: use of hyperpolarized magnetic resonance spectroscopy
Dominique Meynial-Denis1 and Jean-Pierre Renou2

GLUTAMINE, IMMUNITY AND EXERCISE

Glutamine and the immune system: an overview
Philip Calder

Glutamine and exercise and immune system
Marcelo Macedo Rogero

The Role of Glutamine in Exercise-induced Immunodepression in Humans
Lindy Castell and Natalie Redgrave

GLUTAMINE AND AGING

Glutamine metabolism in old age
Dominique Meynial-Denis

...
View More

Editor(s)

Biography

Dominique Meynial-Denis, Ph.D., is a Researcher at Laboratoire d'Etude de Metabolisme Azote INRA, Centre de Recherches de Clermont-Ferrand-Theix, Lyon, France.