1st Edition

Connective Tissue
Histophysiology, Biochemistry, Molecular Biology





ISBN 9781138034105
Published February 7, 2017 by CRC Press
638 Pages 23 Color & 161 B/W Illustrations

USD $90.95

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Book Description

Connective tissue is a multicomponent, polyfunctional complex of cells and extracellular matrix that serves as a framework for all organs, combining to form a unified organism. It is a structure responsible for numerous vital functions such as tissue–organ integration, morphogenesis, homeostasis maintenance, biomechanical support, and more. The regeneration potential of connective tissue affects healing of damaged tissue and organs, while trauma, stress, and other factors that cause damage to connective tissue can lead to numerous disorders.

Connective Tissue: Histophysiology, Biochemistry, Molecular Biology brings together crucial knowledge of mammalian connective tissue (including human) and its components, both cellular and noncellular, in one authoritative reference. The breadth and depth of information has fundamental scientific significance as well as applied relevance in clinical medicine. The first half of the book covers the structure, classification, biochemical aspects, histogenesis, and cellular elements of connective tissue. It presents data from the macro- to nanolevel organization of the extracellular matrix—its structural and functional aspects—and addresses metabolic functions and the biochemistry and molecular biology of connective tissue ageing.

The second half of the book reviews current data on the biochemistry and molecular biology of skeletal connective tissue, including bone and cartilage metabolism and regulation. It presents an in-depth analysis of data on the molecular mechanisms of connective tissue ontogenesis, from embryonic development through ageing. It also reports novel findings on bone marrow stroma and describes electron microscopy results of the nanostructure of bone mineral, mineralized cartilage, and teeth compared with coral and seashells. Comprising both classic and modern data on the histopathology, biochemistry, and molecular biology of connective tissue, this book provides a unique resource for clinicians and researchers alike.

Table of Contents

Peculiarities of Connective Tissue Histophysiology, Biochemistry, and Molecular Biology
Definitions, Organization Principles, and Classification of Connective Tissue
Basic Definitions, Principles and Emphasis of Modern Biochemistry and Molecular Biology
General Biochemical Aspects of Connective Tissue
Formation and Histogenesis of Connective Tissue
Embryology and Histogenesis of Connective Tissue
Molecular and Biochemical Regularities of Initial Stages of Connective Tissue Structures Formation

Cellular Elements of Connective Tissue
Proper Cells of Connective Tissue
Fibroblastic Differon
Adventitious Cells
Adipocytes(Lipocytes, Adipocytes)
Cells Associated with Connective Tissue

Extracellular Matrix of Connective Tissue: Histophysiology, Biochemistry and Molecular Biology
Fibrous Structures
Integrating Buffer Metabolic Medium (Ground Substance) of Connective Tissue Extracellular Matrix
Basement Membranes
Interstitial (Interfibrous and Intercellular) Space of Connective Tissue
Structural Peculiarities of Connective Tissue Various Types and its Organ Specificity
General Regularities of Molecular and Supramolecular Organization of Connective Tissue Extracellular Matrix. Molecular Mechanisms of Cells and Matrix Interaction
Catabolism of Extracellular Matrix Macromolecular Components

Regulation of Connective Tissue Metabolic Functions
Systemic Factors of Regulation
Local Factors of Regulation

Biochemical and Molecular Mechanisms and Manifestations of Connective Tissue Ageing

Bone – An Organ of the Support and Locomotor Apparatus Containing All Types of Connective Tissue
Overview of Bone Structure and Function
General Structural and Functional Characteristics of Bone Components

Cartilage – Cartilaginous Tissue: Structural, Biochemical and Molecular Biological Characteristics
Overview of Structure and Composition of Cartilage Tissue
Hyaline Cartilages – Cartilaginous Tissues
Elastic Cartilages – Cartilaginous Tissues
Fibrous Cartilages – Cartilaginous Tissues

Bone Tissue: The Structural-Functional, Biochemical and Molecular Biological Characteristics of Its Components
General Overview of Bone Tissue Structure and Composition
Differons of Bone Cells
Extracellular Matrix of Bone Tissue
Interstitial Space of Bone Tissue
Regulation Mechanisms of Bone Tissue Metabolism and Functions
Remodeling of Bone Tissue
Tooth Connective Tissue

Biochemical Characteristics of Synovial Membrane and Synovia
Synovial membrane
Synovia (Synovial Fluid)

Molecular Biological and Biochemical Regularities of Connective Tissue Structures Ontogenesis
Molecular Biological and Biochemical Mechanisms of Mesenchyme Condensation. Regulation Systems of Connective Tissue Structure Morphogenesis
Differentiation of Connective Tissue Cells
Molecular Biological and Biochemical Regularities of Skeleton Formation and Growth
Molecular Biological and Biochemical Mechanisms of Joint Formation

References

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Author(s)

Biography

Nikolay Petrovich Omeliyanenko, Doctor of Medicine, Professor, Member of the New York Academy of Sciences, Winner of the Prize of the Russian Federation Government, the Chief of the Laboratory of Connective Tissue of the Central Research Institute of Traumatology and Orthopedics of N.N. Priorov, the Department of Public Health of the Russian Federation. The scientific interests: structural and functional organization of bone, cartilaginous tissue and other connective tissue types in health, regeneration and pathology.

Leonid Ilyich Slutsky, Professor Emeritus, Doctor Habilitatus of Medicine. In 1960–1996 – the Chief of the Laboratory of Biochemistry of the Riga Research Institute of Traumatology and Orthopedics (Latvia). The main scientific interests: biochemistry of the connective tissue and skeleton.

Sergey Pavlovich Mironov, Doctor of Medicine, Professor, Academician of the Russian Academy of Sciences and Russian Academy of Medical Sciences, Honoured Worker of Science of the Russian Federation, Winner of the State Prize and the Prize of the Russian Federation Government, the Head of the Central Research Institute of Traumatology and Orthopaedics of N.N. Priorov, the Department of Public Health of the Russian Federation. Field of research: clinical and fundamental orthopedics and traumatology.